Fasting test?You do not need to be fasting for this blood test. It is important not to stop eating gluten in the weeks and days prior to this test. The results take an average of 5 working days.
Celiac disease - What is it?Celiac disease is an autoimmune disease in which there is intolerance to a protein in gluten. Gluten is found in grain products, such as wheat, bread and pasta. People with a gluten allergy are hypersensitive and quickly develop complaints such as stomach pain. This is often after eating, but it can also be a while later. The best treatment for celiac disease is to avoid gluten. In the supermarket you increasingly see gluten-free alternatives.
Celiac disease is an autoimmune disease in which the body's immune cells attack the intestinal mucosa. This causes atrophy of the intestinal mucosa. When a visual examination is performed, one sees smooth mucous membrane of the intestines, we call this villous atrophy. Visual examination is the best diagnostic tool, but this is a rather unpleasant method to arrive at the diagnosis. Another option is blood tests.
When there is villous atrophy, nutrients such as vitamins are not absorbed properly. This can cause fatigue, depression, anemia and osteoporosis, in addition to diarrhea and constipation. These are very diverse complaints, so celiac disease is not immediately considered.
We measure markers that demonstrate celiac disease with a blood test. This was previously done with three markers, namely endomysium IgA, anti-tTG and total IgA. The blood test for celiac disease today is accurate with just the anti-tTG.
What do we determine?
Tissue transglutaminaseAntibodies against tissue transglutaminase are based on the presence of IgA antibodies, a protein of the immune system. If there is an IgA deficiency, this test is less reliable. If this is the case and the results are in the gray zone, additional free deamidated gliadin IgG will be requested.
Endomysium AntibodiesEndomysial antibodies of class IgA are not unique to the diagnosis of celiac disease, but can also occur in other diseases. The level of the titer often corresponds to the severity of the villous atrophy in celiac disease. After starting a gluten-free diet, the titer will drop within 6-12 months. Because these antibodies are not specific for the diagnosis of celiac disease, they are no longer determined nowadays.
Total IgAIgA stands for antibody A. Our immune system has many different immune cells. However, we know some of the antibodies (such as IgM, IgG and IgE). With celiac disease there is often a decrease in the concentration of IgA antibodies. If the tissue transglutaminase gives rise to this, the total IgA is also measured.
When to choose this blood test?Choose the celiac blood test when:
- You suspect have a gluten allergy
- You have misunderstood abdominal pain complaints and do not think about IBS
- You suffer from diarrhea or constipation that gets worse with eating of gluten