In certain conditions, prolonged and elevated levels of serum amyloid A can lead to the deposition of amyloid fibrils in various tissues, contributing to the development of amyloidosis. Amyloidosis is a group of conditions characterized by the abnormal accumulation of amyloid proteins in organs and tissues, which can affect their normal function.
It is important to note that although serum amyloid A is associated with inflammation and certain diseases, it is only one component of a complex immune response. Monitoring SAA levels can provide valuable information about the level of inflammation in the body and can aid in the diagnosis and treatment of related conditions.
SAA acts as an inflammatory marker. When inflammation occurs in the body, the production of SAA increases.
Increased Levels: Increased levels of SAA can be seen in various inflammatory conditions, such as rheumatoid arthritis, infections, and autoimmune diseases.
Prolonged and significant elevations in SAA levels can lead to the formation of amyloid plaques. Amyloidosis is a condition in which these plaques build up in various tissues and organs, which can cause damage to these structures.
Diagnosis and Monitoring:
Measurements of SAA levels can be used for the diagnosis and monitoring of inflammatory conditions. Doctors can use these tests to assess the severity of inflammation and monitor the effectiveness of treatments.